Effects of Lipoic Acid and High-Intensity Interval Training (HIIT) on Pancreatic VEGFR-3 Levels in Diabetic Rat Model

Hashemian Esfahani, Seyed Ramin; Dadban Shahamat, Minoo; Askari, Asra; Nezhadebrahimi, Abbas

doi:10.18502/ijdo.v16i2.15709

Volume 16, Issue 2 (6-2024) IJDO 2024, 16(2): 103-111 | Back to browse issues page

‎ 10.18502/ijdo.v16i2.15709

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Hashemian Esfahani S R, Dadban Shahamat M, Askari A, Nezhadebrahimi A. Effects of Lipoic Acid and High-Intensity Interval Training (HIIT) on Pancreatic VEGFR-3 Levels in Diabetic Rat Model. IJDO 2024; 16 (2) :103-111
URL: http://ijdo.ssu.ac.ir/article-1-873-en.html

Effects of Lipoic Acid and High-Intensity Interval Training (HIIT) on Pancreatic VEGFR-3 Levels in Diabetic Rat Model

Seyed Ramin Hashemian Esfahani

, Minoo Dadban Shahamat ^*

, Asra Askari

, Abbas Nezhadebrahimi

Department of Physical Education, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran.

Abstract: (252 Views)

Objective: The purpose of this experimental research is to investigate the effects of High-Intensity Interval Training (HIIT) and Lipoic Acid )ALA( supplementation on VEGFR-3 of pancreatic in diabetic Wistar rats model.
Materials and Methods: 20 male Wistar rats weighing 159 ± 3 gr and aged3 weeks, were randomly assigned into 4 groups:1) diabetes/sham, 2)diabetes/ ALA, 3)diabetes/exercise/sham, and 4) diabetes /exercise/ ALA. Diabetes was induced with streptozotocin (65 mg/kg dose) and Nicotinamide (120 mg/kg dose). After two weeks of familiarization with interval training, the rats started their main training, included 10 repetitions of 4 minutes of running on the treadmill with an intensity of 85-90% VO2max and 2 minutes of active rest between repetitions (5-10 m/min) for 5 sessions per week for 6 weeks. ALA supplement was taken at a dose of 20 mg/kg/day for 6 weeks. One-way ANOVA test used and Tukey's post hoc test at for analysis (P≤ 0.05).
Results: HIIT has a significant effect on blood glucose (P= 0.004) and insulin (P= 0.001) and VEGFR3 (P= 0.001) of pancreatic tissue of diabetic rats.
Conclusion: Lymphatic vessels play an important role in the pancreas and treat diabetes.The results of this research showed that HIIT and ALA increased lymphangiogenesis in the diabetic rat model.

Keywords: ALA, HIIT, Lymph angiogenesis, Diabetic model rats

Full-Text [PDF 478 kb] (157 Downloads)

Type of Study: Research | Subject: Special
Received: 2023/11/23 | Accepted: 2024/04/6 | Published: 2024/06/21

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